Development of an on-line solid phase extraction ultra-high-performance liquid chromatography technique coupled to tandem mass spectrometry for quantification of bisphenol S and bisphenol S glucuronide: Applicability to toxicokinetic investigations
نویسندگان
چکیده
منابع مشابه
Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry.
Bisphenol A (BPA) is a weak estrogen. Pharmacokinetic studies of BPA have demonstrated a rapid and extensive metabolism of BPA to the nonestrogenic BPA-monoglucuronide (BPA-gluc). Some investigators have reported that BPA was found at parts per billion concentrations in the tissues or urine of humans without known exposure to BPA. This work developed a rapid and sensitive method for the determi...
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Quantification of the new immunosuppressant sirolimus (syn. rapamycin; Rapamune) in whole blood by chromatography is essential for its clinical use since no immunoassay is available although monitoring is mandatory. Here we report on a rapid and convenient liquid chromatography (LC-tandem mass spectrometry method and describe our practical experience with its routine use. Whole blood samples we...
متن کاملMeasurement of Bisphenol-A in Human Urine by Ultra-Performance Liquid Chromatography/Tandem Mass Spectrometry
A simple and rapid ultra-performance liquid chromatographic tandem mass spectrometric assay for the measurement of bisphenol-A (BPA) in human urine was developed and validated. Sample preparation involved addition of 4-nitrophenol (as an internal standard, IS) to 1.0 ml human urine sample containing BPA, and extraction with ethyl acetate and hexane (6:4,v:v), evaporation, and dissolving the res...
متن کاملAn on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry.
BACKGROUND Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. METHODS Following protein precipitation, on-line solid phase extraction was performed for sam...
متن کاملQSRR models of veterinary drugs in milk in ultra-performance liquid chromatography coupled to time of flight mass spectrometry
The veterinary drugs residues are also important pollutants found in milk, since veterinary drugs are commonly used in cattle management. Considering the role of milk in human nutrition and its wide consumption throughout the world, it is very important to ensure the milk quality. A quantitative structure–retention relationship (QSRR) was developed using the partial least square (PLS), Kernel P...
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ژورنال
عنوان ژورنال: Journal of Chromatography A
سال: 2017
ISSN: 0021-9673
DOI: 10.1016/j.chroma.2017.10.020